logo ininstituto Cajal logo Desarrollo Sostenible logo CSIC

Inicio

linea

Español

linea

English

    
 
Es tiempo de investigaci⊐D17Fn, es tiempo de vida, ....es tiempo de CSIC

biblioteca cajal

Cómo llegar al instituto Cajal

legado Cajal

biblioteca cajal

  Acceso a intranet
 

Intranet CSIC
Intranet Cajal

 

   banner Cajal

Departamentos > Neurobiología Molecular, Celular y del Desarrollo > Generación y Degeneración Neuronal en Vertebrados > Publicaciones

Investigación Personal Publicaciones Otros

Publicaciones

  • Walton CC, Zhang W, Patiño-Parrado I, Barrio-Alonso E, Garrido JJ y Frade JM. (2019) Primary neurons can enter M-phase. Sci. Rep. 9: 4594.

  • Villoslada P, Vila G, Colafrancesco V, Moreno B, Fernandez-Diez B, Vazquez R, Pertsovskaya I, Zubizarreta I, Pulido-Valdeolivas I, Messeguer J, Vendrell-Navarro G, Frade JM, López-Sánchez N, Teixido M, Giralt E, Masso M, Dugas JC, Leonoudakis D, Lariosa-Willingham KD, Steinman L y Masseguer A. (2019) Axonal and myelin neuroprotection by the peptoid BN201 in brain inflammation. Neurotherapeutics (en prensa).

  • Barrio-Alonso E, Hernández-Vivanco A, Walton, CC, Perea G y Frade JM (2018) Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons. Sci. Rep. 8:14316.

  • Frade JM y López-Sánchez N Neuronal tetraploidy in Alzheimer and Aging Aging (en prensa).

  • López-Sánchez N y Frade JM. (2017) A mutant form of E2F4 prevents neuronal tetraploidization and cognitive deficits in 5xFAD mice without affecting Abeta deposition. Alzheimer’s & Dementia 13 (Supplement): P659–P661.

  • Frade JM y Gage FH (2017) Genomic Mosaicism in neurons and other cell types. Springer Nature, New York. ISBN: 978-1-4939-7279-1 (eBook ISBN 978-1-4939-7280-7).

  • Frade JM y Gage FH (2017) Preface. In: Genomic Mosaicism in neurons and other cell types (Eds. Jose M. Frade and Fred H. Gage). Springer Verlag, New York, pág. vii-x.

  • López-Sánchez N, Patiño-Parrado I y Frade JM (2017) Quantification, isolation, and subsequent epigenetic analysis of tetraploid neurons by flow cytometry. In: Genomic Mosaicism in neurons and other cell types (Eds. Jose M. Frade and Fred H. Gage). Springer Verlag, New York, pág. 57-80.

  • Patiño-Parrado I, García-Gómez A, López-Sánchez N y Frade JM (2017) Strand-specific CpG hemimethylation, a novel epigenetic modification functional for gene silencing. Nucl. Acids Res. 45: 8822–8834.

  • López-Sánchez N, Fontán-Lozano Á, Pallé A, González-Álvarez V, Rábano A, Trejo JL y Frade JM (2017) Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology. Neurobiol. Aging. 56: 50-66.

  • Slaninová I, López-Sánchez N, Šebrlová K, Vymazal O, Frade JM y Taborská E (2016) Introduction of Macarpine as a novel cell-permeant DNA dye for live cell imaging and flow cytometry sorting. Biol. Cell 108: 1-18.

  • Ovejero-Benito MC y Frade JM (2015) p27Kip1 participates in the regulation of endoreduplication in differentiating chick retinal ganglion cells. Cell Cycle 14: 2311-2322.

  • Frade JM y Ovejero-Benito MC (2015) Neuronal cell cycle: the neuron itself and its circumstances. Cell Cycle 14: 712-720.

  • López-Sánchez N y Frade JM (2015) Flow cytometric analysis of DNA synthesis and apoptosis in the central nervous system using fresh cell nuclei. Methods Mol. Biol. 1254: 33-42.

  • Galan A, Dergham P, Escoll P, de la Hera A, D’Onofrio PM, Magharious MM, Koeberle PD, Frade JM, Saragovi HU (2014) Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells. PLoS One 9: e101349.

  • López-Sánchez N, Ovejero-Benito MC, Rodríguez-Ruiz C y Frade JM (2013) NGF/p75NTR in cell cycle and neuronal tetraploidy. En: The Handbook of Neurotoxicity (Ed. Richard Kostrzewa). Springer Verlag, Heidelberg, páginas 1877-1897.

  • Ovejero-Benito MC y Frade JM (2013) Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. PLoS One 5: e64890. doi:10.1371/journal.pone.0064890.

  • Formosa-Jordan P, Ibañes M, Ares S, y Frade JM (2013) Lateral inhibition and neurogenesis: novel aspects in motion. Int. J. Dev. Biol. 57: 341-350.

  • López-Sánchez N y Frade JM (2013) Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice. J. Neurosci., 33: 7488-7500.

  • Morillo SM, Abanto E, Román MJ y Frade JM (2012) NGF-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. Mol. Cell. Biol. 32: 2722-2737.

  • Formosa P, Ibañes M, Ares S y Frade JM (2012) Regulation of neuronal differentiation at the neurogenic wave front. Development 139: 2321-2329.

  • Santos AM, López-Sánchez N, Martín-Oliva D, de la Villa P, Cuadros MA y Frade JM (2012) Sortilin participates in light-dependent photoreceptor degeneration in vivo. PLoS One 7: e36243. 

  • García-Domínguez DJ, Morello D, Cisneros E, Kontoyiannis DL y Frade JM (2011) Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis. Mol. Biol. Cell.22: 1227-1239.

  • López-Sánchez N, Ovejero-Benito MC, Borreguero L y Frade JM (2011) Control of neuronal ploidy during vertebrate development. En: Cell cycle in Development (Ed. Jacek Z. Kubiak).Springer Verlag. pág. 547-563. Results Probl. Cell Differ. 53: 547-563.

  • Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Zhang L, Bibel M, Barde YA (2010) Neurotrophin receptors TrkA and TrkC but not TrkB cause neuronal death. Nature 467: 59-64.

  • Frade JM y López-Sánchez (2010) A novel hypothesis for Alzheimer's disease based on neuronal tetraploidy induced by p75NTR. Cell Cycle 9: 1934-1941.

  • Frade JM (2010) Somatic tetraploidy in vertebrate neurons: implications in physiology and pathology. Commun. Integr. Biol. 3: 201-203.

  • Morillo SM, Escoll P, de la Hera A, y Frade JM (2010) Somatic tetraploidy in specific chick retinal ganglion cells induces by nerve growth factor. Proc. Natl. Acad. Sci. USA 107: 109-114.

  • Latasa MJ, Cisneros E, y Frade JM (2009) Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis. Int. J. Dev. Biol. 53: 895-908.

  • Morillo SM y Frade JM (2008) Nerve growth factor signaling in neural cancer and metastasis. En: Nerve Growth Factor: New Research (Ed. Guy K. MacIntire). NOVA Science Publishers, Inc., New York (en prensa).

  • Cisneros E, Latasa MJ, García-Flores M y Frade JM (2008) Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase. Mol. Cell. Neurosci. 37: 820-831.

  • López-Sánchez N, González-Fernández Z, Niinobe M, Yoshikawa K y Frade JM (2007a) Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins. Physiol. Genomics 30: 156-171.

  • López-Sánchez N, Rodríguez JR y Frade JM (2007b) Mitochondrial c-Jun N-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support. Mol. Cancer Res. 5: 47-60. [Cover caption]

  • Frade JM (2006) Type II MAGE proteins at the crossroads of cell death and neurogenesis. En: Trends in Signal Transduction Research (Ed. Jennifer N. Meyers). NOVA Science Publishers, Inc., New York, pág. 55-74.

  • Frade JM (2005) Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J. Neurosci. 25: 1407-1411.

  • López-Sánchez N, Müller U y Frade JM (2005) Lengthening of G2/mitosis in cortical precursors from mice lacking β-amyloid precursor protein. Neurosci. 130: 51-60.

  • López-Sánchez N y Frade JM (2002) Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor. Histol. Histopathol. 17: 1227-1237.

  • Frade JM (2002) Interkinetic nuclear movement in the vertebrate neuroepithelium: encounters with an old acquaintance. Prog. Brain Res. 136: 67-71.

  • Murciano A, Zamora J, López-Sánchez J y Frade JM (2002) Interkinetic nuclear movement may provide spatial clues to the regulation of neurogenesis. Mol. Cell. Neurosci. 21: 285-300.

  • Frade JM (2000) Unscheduled cell cycle re-entry induced by NGF precedes cell death in nascent retinal neurones. J. Cell Sci.113: 1139-1148.

  • Frade JM (2000) NRAGE and the cycling side of the neurotrophin receptor p75. Trends Neurosci. 23: 591-592.

  • Frade JM, y Rodríguez-Tébar A (2000). Neuroepithelial differentiation induced by ECM molecules. Methods Mol. Biol. 139: 257-264.

Cinco publicaciones más relevantes del grupo:

  • Patiño-Parrado I, García-Gómez A, López-Sánchez N y Frade JM (2017) Strand-specific CpG hemimethylation, a novel epigenetic modification functional for gene silencing. Nucl. Acids Res. 45: 8822–8834.

  • Formosa P, Ibañes M, Ares S y Frade JM (2012) Regulation of neuronal differentiation at the neurogenic wave front. Development 139: 2321-2329.

  • Morillo SM, Escoll P, de la Hera A, y Frade JM (2009) Somatic Tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc. Natl. Acad. Sci. USA 107: 109-114.

  • Frade JM (2005) Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J. Neurosci. 25: 1407-1411.

  • Frade JM (2000) Unscheduled cell cycle re-entry induced by NGF precedes cell death in nascent retinal neurones. J. Cell Sci.113: 1139-1148.

Portadas de publicaciones relevantes:

Inicio Instituto Cajal Departamentos Personal Publicaciones Noticias Biblioteca Enlaces Acceso intranet Contacto Politica de privacidad y avisos legales  
Av. Doctor Arce, 37. 28002 Madrid - España • Tel.: +34 915854750 • Fax.: +34 915854754 • Síguenos en Twitter