Laboratorio de Neuroendocrinologia

Principales publicaciones

M.A. Castro-Alamancos, I. TORRES-ALEMAN. Long-term depression of glutamate-induced gamma aminobutyric acid release in cerebellum by insulin-like growth factor I. Proc. Nat. Acad. Sci. (USA) 90: 7386-7390, (1993).

M.A. Castro-Alamancos, I. TORRES-ALEMAN. Learning of the conditioned eye-blink response is impaired by an antisense insulin-like growth factor I oligonucleotide. Proc. Nat. Acad. Sci. (USA) 91: 10203-10207, (1994).

I. TORRES-ALEMAN, V. Barrios, A. Lledó, J. Berciano. The insulin-like growth factor system in cerebellar degeneration. Ann. Neurol., 39: 335-342, (1996).

A.M. Fernandez, A. Gonzalez de la Vega, I. TORRES-ALEMAN. Insulin-like growth factor restores motor coordination in a rat model of cerebellar ataxia. Proc. Nat. Acad. Sci. (USA) 95: 1253-1258 (1998).

I. TORRES-ALEMAN, V. Barrios, J. Berciano. The peripheral insulin-like growth factor system in amyotrophic lateral sclerosis and multiple sclerosis. Neurology 50: 772-776, (1998).

E. Carro, A. Nuñez, S. Busiguina, I. TORRES-ALEMAN. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 20: 2926-2933 (2000).

J.L. Trejo, E. Carro, I. TORRES-ALEMAN. Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus. J. Neurosci. 21, 1628-1634 (2001).

E. Carro, J.L. Trejo, S. Busiguina, I. TORRES-ALEMAN. Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J. Neurosci. 21, 5678-5684 (2001).

E. Carro, J.L. Trejo, T. Gomez-Isla, D. LeRoith, I. TORRES-ALEMAN. Serum insulin-like growth factor I regulates brain amyloid levels. Nature Med. 8, 1390-1397 (2002).

C. Lopez Lopez, D. LeRoith, I. TORRES-ALEMAN . Insulin-like growth factor I is required for vessel remodelling in the adult brain. Proc. Nat. Acad. Sci. (USA) 101, 9833-9838 (2004).

E. Carro, C. Spuch, J.L. Trejo, D. Antequera, I. TORRES-ALEMAN. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J. Neurosci. 25, 10884-10893 (2005).

J.L. Trejo, J. Piriz, M.V. Llorens-Martin, A.M. Fernandez, M. Bolós, D. LeRoith, A. Nuñez, I. TORRES-ALEMAN. Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects. Mol Psych. 12, 1118–1128 (2007).

A. M. Fernandez, S. Fernandez, P. Carrero, M. Garcia-Garcia, and I.TORRES-ALEMAN. Calcineurin in reactive astrocytes plays a key role in the interplay between pro- and anti-inflammatory signals. J. Neurosci. 27, 8745-8756 (2007).

C. Lopez-Lopez, M.O. Dietrich, F. Metzger, H. Loetscher, and I. TORRES-ALEMAN. Disturbed cross-talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the APP/PS2 mouse model of Alzheimer´s disease. J. Neurosci. 27, 824-831 (2007).

T. Nishijima, J. Piriz, S. Duflot, A.M. Fernandez, G. Gaitan, U. Gomez-Pinedo, J.M. Verdugo, F. Leroy, H. Soya, A. Nuñez, TORRES-ALEMAN I. Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron 67, 834-846 (2010).

A.M. Fernandez, I. TORRES-ALEMAN. The many faces of insulin-like peptide signaling in the brain. Nature Reviews Neuroscience 13, 225-239 (2012).

A.M Fernandez, S. Jimenez, M. Mecha, D. Davila, C. Guaza, J. Vitorica, I. TORRES-ALEMAN. Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role astrocytes in Alzheimer´s pathology. Mol Psychiatry 17, 705-718 (2012)

S. Fernandez, L. Genis, I.TORRES-ALEMAN. A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-I loop. Oncogene 33, 4114-22 (2014)

C. Garcia-Caceres, C. Quarta, Y. Gao, L. Varela, T. Gruber, B. Legutko, M. Jastroch, P. Johansson, J. Ninkovic, C.X. Yi, O. Le Thuc, C. Meyer, P.T. Pfluger, A.M. Fernandez, S. Luquet, S.C. Woods, I. TORRES-ALEMAN, C.R. Kahn, M. Götz, T. Horvath, M.H. Tschöp. Astrocytic insulin signaling couples brain glucose uptake with nutrient availability. Cell 166, 867-880 (2016).

E. Hernandez-Garzón, AM Fernandez, A Perez-Alvarez, L Genis, P Bascuñana, R Fernandez de la Rosa, M Delgado, MA Pozo, E Moreno, PJ McCormick, A Santi, A Trueba-Saiz, C Garcia-Caceres, M H. Tschöp, A Araque, ED Martin, and I TORRES ALEMAN. The insulin-like growth factor receptor I regulates glucose transport by astrocytes. Glia 64, 1962-1971 (2016).

A.M. Fernandez, E. Hernandez-Garzón, P. Perez-Domper, A. Perez-Alvarez, S. Mederos, T. Matsui, A. Santi, A. Trueba-Saiz, L. García-Guerra, J. Pose-Utrilla, J. Fielitz, E.N. Olson, R. Fernandez de la Rosa, L. Garcia Garcia, M. Angel Pozo, T. Iglesias, A. Araque, H. Soya, G. Perea, E.D. Martin, I. TORRES-ALEMAN. Insulin regulates astrocytic glucose handling through cooperation with insulin-like growth factor I. Diabetes 66, 2017 (in press) http://dx.doi.org/10.2337/db16-0861.

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