Microorganización de la Corteza Cerebral Normal y Alteraciones de los Circuitos

Márquez-Neila P, Baumela L, González-Soriano J, Rodríguez JR, DeFelipe J, Merchán-Pérez A (2016). A Fast method for the segmentation of synaptic junctions and mitochondria in serial electron microscopic images of the brain. Neuroinformatics. 2016 Jan 16. [Epub ahead of print].
Rojo C, Leguey I, Kastanauskaite A, Bielza C, Larrañaga P, DeFelipe J, Benavides-Piccione R (2016). Laminar differences in dendritic structure of pyramidal neurons in the juvenile rat somatosensory cortex. Cereb Cortex. 2016 Jan 12. pii: bhv316. [Epub ahead of print].
Toharia P, Robles OD, Fernaud-Espinosa I, Makarova J, Galindo SE, Rodriguez A, Pastor L, Herreras O, DeFelipe J, Benavides-Piccione R (2016). PyramidalExplorer: A new interactive tool to explore morpho-functional relations of human pyramidal neurons. Front Neuroanat. 9:159.
Leguey I, Bielza C, Larrañaga P, Kastanauskaite A, Rojo C, Benavides-Piccione R, DeFelipe J (2016). Dendritic branching angles of pyramidal cells across layers of the juvenile rat somatosensory cortex. J Comp Neurol. doi: 10.1002/cne.23977. [Epub ahead of print]
Mellström B, Kastanauskaite A, Knafo S, Gonzalez P, Dopazo XM, Ruiz-Nuño A, Jefferys JG, Zhuo M, Bliss TV, Naranjo JR, DeFelipe J (2016). Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice. Mol Brain. 2016 Feb 29;9(1):22. doi: 10.1186/s13041-016-0204-8.
Mihaljevic, B., Benavides-Piccione, R., Guerra, L., DeFelipe, J., Larrañaga, P. & Bielza, C. (2015). Classifying GABAergic interneurons with semi-supervised projected model-based clustering. Artif Intell Med. 2015 Jan 2. pii: S0933-3657(14)00148-1. doi: 10.1016/j.artmed.2014.12.010.
DeFelipe J (2015) The dendritic spine story: an intriguing process of discovery. Front Neuroanat. 2015 Mar 5;9:14. doi: 10.3389/fnana.2015.00014. eCollection 2015.
Íbias J, Soria-Molinillo E, Kastanauskaite A, Orgaz C, DeFelipe J, Pellón R, Miguéns M (2015). Schedule-induced polydipsia is associated with increased spine density in dorsolateral striatum neurons. Neuroscience. 2015 May 16;300:238-245. doi: 10.1016/j.neuroscience.2015.05.026.
Bosch C, Martínez A, Masachs N, Teixeira CM, Fernaud I, Ulloa F, Pérez-Martínez E, Lois C, Comella JX, DeFelipe J, Merchán-Pérez A, Soriano E (2015) FIB/SEM technology and high-throughput 3D reconstruction of dendritic spines and synapses in GFP-labeled adult-generated neurons. Front Neuroanat. 2015 May 21;9:60. doi: 10.3389/fnana.2015.00060. eCollection 2015.
Montes J, Peña JM, DeFelipe J, Herreras O, Merchan-Perez A. The influence of synaptic size on AMPA receptor activation: a Monte Carlo model. PLoS One. 2015 Jun 24;10(6):e0130924. doi: 10.1371/journal.pone.0130924. eCollection 2015.
Rábano A, Cuadros R, Merino-Serráis P, Rodal I, Benavides-Piccione R, Gómez E, Medina M, DeFelipe J, Avila J. Protocols for Monitoring the Development of Tau Pathology in Alzheimer's Disease. Methods Mol Biol. 2016, 1303:143-60. doi: 10.1007/978-1-4939-2627-5_7.
Selvas A, Coria SM, Kastanauskaite A, Fernaud-Espinosa I, DeFelipe J, Ambrosio E, Miguéns M (2015). Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration. Addict Biol. 2015 Sep 2. doi: 10.1111/adb.12294.
DeFelipe J (2015). The anatomical problem posed by brain complexity and size: a potential solution. Front Neuroanat. 9:104. doi: 10.3389/fnana.2015.00104. eCollection 2015.
Markram H, Muller E, Ramaswamy S, Reimann MW, Abdellah M, Sanchez CA, Ailamaki A, Alonso-Nanclares L, Antille N, Arsever S, Kahou GA, Berger TK, Bilgili A, Buncic N, Chalimourda A, Chindemi G, Courcol JD, Delalondre F, Delattre V, Druckmann S, Dumusc R, Dynes J, Eilemann S, Gal E, Gevaert ME, Ghobril JP, Gidon A, Graham JW, Gupta A, Haenel V, Hay E, Heinis T, Hernando JB, Hines M, Kanari L, Keller D, Kenyon J, Khazen G, Kim Y, King JG, Kisvarday Z, Kumbhar P, Lasserre S, Le Bé JV, Magalhães BR, Merchán-Pérez A, Meystre J, Morrice BR, Muller J, Muñoz-Céspedes A, Muralidhar S, Muthurasa K, Nachbaur D, Newton TH, Nolte M, Ovcharenko A, Palacios J, Pastor L, Perin R, Ranjan R, Riachi I, Rodríguez JR, Riquelme JL, Rössert C, Sfyrakis K, Shi Y, Shillcock JC, Silberberg G, Silva R, Tauheed F, Telefont M, Toledo-Rodriguez M, Tränkler T, Van Geit W, Díaz JV, Walker R, Wang Y, Zaninetta SM, DeFelipe J, Hill SL, Segev I, Schürmann F (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell. 163:456-92. doi: 10.1016/j.cell.2015.09.029.
Ramaswamy S, Courcol JD, Abdellah M, Adaszewski SR, Antille N, Arsever S, Atenekeng G, Bilgili A, Brukau Y, Chalimourda A, Chindemi G, Delalondre F, Dumusc R, Eilemann S, Gevaert ME, Gleeson P, Graham JW, Hernando JB, Kanari L, Katkov Y, Keller D, King JG, Ranjan R, Reimann MW, Rössert C, Shi Y, Shillcock JC, Telefont M, Van Geit W, Villafranca Diaz J, Walker R, Wang Y, Zaninetta SM, DeFelipe J, Hill SL, Muller J, Segev I, Schürmann F, Muller EB, Markram H (2015). The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex. Front Neural Circuits. 9:44. doi: 10.3389/fncir.2015.00044.
Chamorro-López J, Miguéns M, Morgado-Bernal I, Kastanauskaite A, Selvas A, Cabané-Cucurella A, Aldavert-Vera L, DeFelipe J, Segura-Torres P (2015). Structural plasticity in hippocampal cells related to the facilitative effect of intracranial self-stimulation on a spatial memory task. Behav Neurosci. 129:720-730.
Luengo-Sanchez S, Bielza C, Benavides-Piccione R, Fernaud-Espinosa I, DeFelipe J, Larrañaga P (2015). A univocal definition of the neuronal soma morphology using Gaussian mixture models. Front Neuroanat. 9:137.
Antón-Fernández A, León-Espinosa G, DeFelipe J, Muñoz A (2015). Changes in the Golgi Apparatus of Neocortical and Hippocampal Neurons in the Hibernating Hamster. Front Neuroanat. 9:157.
Ferreira FR, Nogueira MI, DeFelipe J (2014). The influence of James and Darwin on Cajal and his research into the neuron theory and evolution of the nervous system. Front Neuroanat. 8:1. doi: 10.3389/fnana.2014.00001.
Toharia P, Morales J, de Juan O, Fernaud I, Rodríguez A, DeFelipe J (2014) Musical representation of dendritic spine distribution: A new exploratory tool. Neuroinformatics. 2014 Apr;12(2):341-53.
Mellström B, Sahún I, Ruiz-Nuño A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higuera-Matas A, Errington ML, Maldonado R, DeFelipe J, Jefferys JG, Bliss TV, Dierssen M, Naranjo JR (2014) DREAM controls the on/off switch of specific activity-dependent transcription pathways. Mol Cell Biol 34:877-887.
Jimenez-Mateos EM, Engel T, Merino-Serrais P, Fernaud-Espinosa I, Rodriguez-Alvarez N, Reynolds J, Reschke CR, Conroy RM, McKiernan RC, DeFelipe J, Henshall DC. Antagomirs targeting microRNA-134 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. Brain Struct Funct. 2014 May 30. [Epub ahead of print]
Llorens-Martín M, Blazquez-Llorca L, Benavides-Piccione R, Rabano A, Hernandez F, Avila J, DeFelipe J (2014). Selective alterations of neurons and circuits related to early memory loss in Alzheimer's disease. Front Neuroanat. 2014 May 27;8:38. doi: 10.3389/fnana.2014.00038.
Bielza C, Benavides-Piccione R, López-Cruz P, Larrañaga P, DeFelipe J (2014). Branching angles of pyramidal cell dendrites follow common geometrical design principles in different cortical areas. Sci. Rep. 4, 5909; DOI:10.1038/srep05909.
Morales J, Ruth Benavides-Piccione R, Dar M, Fernaud I, Rodríguez A, Anton-Sanchez L, Bielza C, Larrañaga P, DeFelipe J, Yuste R (2014). Random Positioning of Dendritic Spines in the Human Cerebral Cortex. J Neurosci. 34:10078-10084. doi: 10.1523/JNEUROSCI.1085-14.2014.
Anton-Sanchez L, Bielza C, Merchán-Pérez A, Rodríguez J-R, DeFelipe J and Larrañaga P (2014). Three-dimensional distribution of cortical synapses: a replicated point pattern-based analysis. Front.Neuroanat. 8:85. doi:10.3389/fnana.2014.00085.
DeFelipe J, Garrido E, Markram H (2014) The death of Cajal and the end of scientific romanticism and individualism. Trends Neurosci. 37(10): 525-527. doi: 10.1016/j.tins.2014.08.002.
Corenthy L, Garcia M, Bayona S, Santuy A, San Martin J, Benavides-Piccione R, DeFelipe J, Pastor L (2014) Haptically Assisted Connection Procedure for the Reconstruction of Dendritic Spines. IEEE Trans Haptics. 2014 Sep 4. [Epub ahead of print]
Mihaljević B, Bielza C, Benavides-Piccione R, DeFelipe J, Larrañaga P (2014) Multi-dimensional classification of GABAergic interneurons with Bayesian network-modeled label uncertainty. Front Comput Neurosci. 2014 Nov 25;8:150. Doi: 10.3389/fncom.2014.00150.
Mihaljević B, Benavides-Piccione R, Bielza C, DeFelipe J, Larrañaga P (2014) Bayesian Network Classifiers for Categorizing Cortical GABAergic Interneurons. Neuroinformatics. 2014 Nov 25. [Epub ahead of print]
Blazquez-Llorca L, Woodruff A, Inan M, Anderson SA, Yuste R, DeFelipe J, Merchan-Perez A. (2014) Spatial distribution of neurons innervated by chandelier cells. Brain Struct Funct. 2014 Jul 24. [Epub ahead of print]
DeFelipe, J. (2013). Going to school to sculpt the brain. Front. Young Minds. 1:1. doi:10.3389/frym.2013.00001
DeFelipe J. Análisis del cerebro: innovación tecnológica y estrategia interdisciplinar. CIC NETWORK 24-28, 2013.
DeFelipe J. Cajal's Butterflies of the Soul. OUPblog as it continues to be a popular title at SFN.
Morales J, Rodríguez A, Rodríguez J-R, DeFelipe J and Merchán-Pérez A (2013) Characterization and extraction of the synaptic apposition surface for synaptic geometry analysis. Front. Neuroanat. 7:20. doi: 10.3389/fnana.2013.00020.
Miguéns M, Kastanauskaite A, Coria SM, Selvas A, Ballesteros-Yañez I, Defelipe J, Ambrosio E (2013) The Effects of Cocaine Self-Administration on Dendritic Spine Density in the Rat Hippocampus Are Dependent on Genetic Background. Cereb Cortex. 2013 Aug 21. [Epub ahead of print]
Montes J, Gomez E, Merchán-Pérez A, Defelipe J, Peña JM (2013) A machine learning method for the prediction of receptor activation in the simulation of synapses. PLoS One. 2013 Jul 23;8(7):e68888.
Brito JP, Mata S, Bayona S, Pastor L, Defelipe J, Benavides-Piccione R. (2013) Neuronize: a tool for building realistic neuronal cell morphologies. Front Neuroanat. 2013;7:15. doi: 10.3389/fnana.2013.00015.
Llorens-Martín M, Fuster-Matanzo A, Teixeira CM, Jurado-Arjona J, Ulloa F, Defelipe J, Rábano A, Hernández F, Soriano E, Avila J. (2013) Alzheimer disease-like cellular phenotype of newborn granule neurons can be reversed in GSK-3Î²-overexpressing mice. Mol Psychiatry. 18(4):395. doi: 10.1038/mp.2013.27
LaTorre, A., Alonso-Nanclares, L., Muelas, S., Peña, J.M., Defelipe, J. (2013) Segmentation of neuronal nuclei based on clump splitting and a two-step binarization of images. Expert Systems with Applications. 40 (16): 6521-30
Alonso-Nanclares L and DeFelipe J (2013). Alterations of the microvascular network in the sclerotic hippocampus of patients with temporal lobe epilepsy. Epilepsy and Behaviour (in press)
LaTorre A, Alonso-Nanclares L, Muelas, S, Peña JM, DeFelipe J (2013). 3D Segmentations of Neuronal Nuclei from Confocal Microscope Image Stacks. Front. Neuroanat. 7:49. doi:10.3389/fnana.2013.00049
Alejandro Antón-Fernández, Pablo Rubio-Garrido, Javier DeFelipe, and Alberto Muñoz (2013) Selective presence of a giant saccular organelle in the axon initial segment of a subpopulation of layer V pyramidal neurons. Brain Structure and Function. [Epub ahead of print].
López-Cruz, P.L., Larrañaga, P., DeFelipe, J., Bielza, C (2013). Bayesian network modeling of the consensus between experts: An application to neuron classification. International Journal of Approximate Reasoning.
Inan M, Blázquez-Llorca L, Merchán-Pérez A, Stewart A. Anderson SA, Javier DeFelipe J, Yuste R. Dense and overlapping innervation of pyramidal neurons by neocortical chandelier cells. J Neurosci 33:1907-14.
Merchán-Pérez A, Rodríguez JR, González S, Robles V, DeFelipe J, Larrañaga P, Bielza C (2013) Three-Dimensional Spatial Distribution of Synapses in the Neocortex: a Dual-Beam Electron Microscopy Study. Cerebral Cortex (in press).
DeFelipe J, López-Cruz PL, Benavides-Piccione R, Bielza C, Larrañaga P, Anderson S, Burkhalter A, Cauli B, Fairén A, Feldmeyer D, Fishell G, Fitzpatrick D, Freund TF, González-Burgos G, Hestrin S, Hill S, Hof PR, Huang J, Jones EG, Kawaguchi Y, Kisvárday Z, Kubota Y, Lewis DA, Marín O, Markram H, McBain CJ, Meyer HS, Monyer H, Nelson SB, Rockland K, Rossier J, Rubenstein JL, Rudy B, Scanziani M, Shepherd GM, Sherwood CC, Staiger JF, Tamás G, Thomson A, Wang Y, Yuste R, Ascoli GA (2013). New insights into the classification and nomenclature of cortical GABAergic interneurons. Nature Neuroscience 14:202-216.
Llorens-Martín M, Fuster-Matanzo A, Teixeira CM, Jurado-Arjona J, Ulloa F, Defelipe J, Rábano A, Hernández F, Soriano E, Avila J. GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo. Mol Psychiatry. 2013 Apr;18(4):451-60.
Blazquez-Llorca L, Merchán-Pérez A, Rodríguez R, Gascón J, Defelipe J (2013) FIB/SEM Technology and Alzheimer's Disease: Three-Dimensional Analysis of Human Cortical Synapses. J Alzheimers Dis 34:995-1013.
Leon-Espinosa G, Garcia E, Garcia-Escudero V, Hernandez F DeFelipe J, Avila,J (2013) Changes in tau phosphorylation in hibernating rodents. J Neurosci Res. J Neurosci Res. 2013 Apr 19. doi: 10.1002/jnr.23220.
Alonso-Nanclares L, Merino-Serrais P, Gonzalez S, DeFelipe J (2013) Synaptic changes in the dentate gyrus of app/ps1 transgenic mice revealed by electron microscopy. J Neuropathol Exp Neurol. 72:386-395.
Armañanzas R, Alonso-Nanclares L, Defelipe-Oroquieta J, Kastanauskaite A, de Sola RG, Defelipe J, Bielza C, Larrañaga P (2013) Machine learning approach for the outcome prediction of temporal lobe epilepsy surgery. PLoS One. 2013 Apr 30;8(4):e62819. doi: 10.1371/journal.pone.0062819.
Merino-Serrais P, Benavides-Piccione R, Blazquez-Llorca L, Kastanauskaite A, Rábano A, Avila J, DeFelipe J (2013) The influence of phosphotau on dendritic spines of cortical pyramidal neurons in Alzheimer’s disease patients. Brain 136:1913-1928.
DeFelipe J, Alonso-Nanclares, L (2013) The synapse: differences between men and women. In: Research and Perspectives in Endocrinology. EDS: Pfaff DW and Christen Y. Springer Berlin Heidelberg, pp 43-57.
DeFelipe J (2013) Cajal and the discovery of a new artistic world: The neuronal forest. Prog Brain Res. 2013;203:201-220. In: The Fine Arts, Neurology and Neuroscience: History and Modem Perspectives. Eds: Stanley Finger, Dahlia Zajdel, Francois Boller and Julien Bogousslavsky. Elsevier, New York
Knafo S, Venero C, Sánchez-Puelles C, Pereda-Peréz I, Franco A, Sandi C, Suárez LM, Solís JM, Alonso-Nanclares L, Martín ED, Merino-Serrais P, Borcel E, Li S, Chen Y, Gonzalez-Soriano J, Berezin V, Bock E, Defelipe J, Esteban JA (2012) Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. PLoS Biol. 2012 Feb;10(2):e1001262.
Martinez de Lagran M, Benavides-Piccione R, Ballesteros-Yañez I, Calvo M, Morales M, Fillat C, DeFelipe J, Ramakers GJ, Dierssen M (2012) Dyrk1a influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons. Cerebr Cortex Jan 2. [Epub ahead of print].
León-Serrano G, DeFelipe J, Muñoz A (2012) Effects of amyloid-β Plaque proximity on the axon initial segment of pyramidal cells. J Alzheimers Dis 29:841-852.
Avila J, León-Espinosa G, García E, García-Escudero V, Hernández F, DeFelipe J (2012) Tau phosphorylation by GSK3 in different conditions. Int J Alzheimers Dis. 2012;2012:578373.
Morales J, Benavides-Piccione R, Rodríguez A, Pastor L, Yuste R, DeFelipe J. (2012) Three-Dimensional Analysis of Spiny Dendrites Using Straightening and Unrolling Transforms. Neuroinformatics 10:391-407.
Benavides-Piccione R, Fernaud-Espinosa I, Robles V, Yuste R, DeFelipe J (2012) Age-Based Comparison of Human Dendritic Spine Structure Using Complete Three-Dimensional Reconstructions. Cereb Cortex. 2012 Jun 17. [Epub ahead of print].
Rockland KS, DeFelipe J (2012) Cortical GABAergic neurons: stretching it. Front Neuroanat. 2012;6:16. Epub 2012 May 31. Front Neuroanat. 2012;6:22.
DeFelipe J, Markram H, Rockland KS (2012) The Neocortical Column. Front Neuroanat. 2012;6:22.
Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, Sano T, O'Tuathaigh C, Waddington JL, Prenter S, Delanty N, Farrell MA, O'Brien DF, Conroy RM, Stallings RL, Defelipe J, Henshall DC (2012). Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med. 18:1087-1094.
Sánchez-Ponce D, DeFelipe J, Garrido JJ, Muñoz A (2012) Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons. Plos One 7 (10):e48557. doi: 10.1371/journal.pone.0048557.
Hof PR, Kidd G, DeFelipe J, de Vellis J, Gama Sosa MA, Elder GA, Trapp BD (2012) Cellular components of nervous tissue. In Fundamental Neuroscience, Fourth Edition: Squire L , Berg D, Bloom FE, du Lac S, Ghosh A, Spitzer NC (Eds), Academic Press, Amsterdam, pp 41-59.
Elston G, Benavides-Piccione R, Elston A, Manger P and Defelipe J (2011). Pyramidal cells in prefrontal cortex: comparative observations reveal unparalleled specializations in neuronal structure among primate species.. Front. Neuroanat. 5:2. doi: 10.3389/fnana.2011.00002.
Rockland KS, DeFelipe J (2011) Cortical white matter: beyond the pale. Front Neuroanat. 2011;5:67.
López, PL, Bielza C, Larrañaga P, Benavides-Piccione R, DeFelipe J (2011) Models and simulation of 3D neuronal dendritic trees using Bayesian networks. Neuroinformatics 9:347-369.
Alonso-Nanclares L, Kastanauskaite A, Rodriguez JR, Gonzalez-Soriano J, DeFelipe J (2011) A stereological study of synapse number in the epileptic human hippocampus. Front. Neuroanat. 5:8. doi: 10.3389/fnana.2011.00008.
Morales J, Alonso-Nanclares L, Rodríguez J-R, DeFelipe J, Rodríguez Á and Merchán-Pérez Á (2011) ESPINA: a tool for the automated segmentation and counting of synapses in large stacks of electron microscopy images. Front. Neuroanat. 5:18. doi: 10.3389/fnana.2011.00018
DeFelipe J (2011) The evolution of the brain, the human nature of cortical circuits and intellectual creativity. Front. Neuroanat. 5:29.
Merino-Serrais P, Knafo S, Alonso-Nanclares L, Fernaud-Espinosa I, Defelipe J (2011). Layer-specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease. Hippocampus 21(10):1037-1044.
Blazquez-Llorca L, Garcia-Marin V, Merino-Serrais P, Avila J and DeFelipe J (2011) Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer’s. J Alzheimer Disease 26 :683-698.
Sánchez-Ponce D, DeFelipe J, Garrido JJ, Muñoz A (2011) In vitro maturation of the cisternal organelle in the hippocampal neuron's axon initial segment. Mol Cell Neurosci. 48:104-116.
Morales J , Alonso-Nanclares L, Rodriguez JR, Merchan-Perez A , DeFelipe J , Rodriguez A (2011) Fast interactive quantification of synapses in the cerebral cortex (2011) .International Journal on Articial Intelligence Tools 20: 239-252.
Sánchez-Ponce D, Blazquez-Llorca L, DeFelipe J, Garrido JJ, Muñoz A (2011) Co-localization of α-actinin and synaptopodin in the pyramidal cell axon initial segment. Cereb Cortex 22:1648-1661.
DeFelipe J and Sotelo C (2011) Goodbye Ted (an Obituary for Edward G. Jones). Front. Neuroanat. 5:44. doi: 10.3389/fnana.2011.00044.
Yague JG, Azcoitia I, DeFelipe J, Garcia-Segura LM, Muñoz A (2010) Aromatase expression in the normal and epileptic human hippocampus. Brain Res. 2010 Feb 22;1315:41-52.
Blazquez-Llorca L, Garcia-Marin V, DeFelipe J (2010) Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer’s disease patients. Front Neuroanat. 4:20. doi:10.3389/fnana.2010.00020
Clancy B, Defelipe J, Espinosa A, Fairén A, Jinno S, Kanold P, Luhmann HJ, Rockland KS, Tamamaki N, Yan XX (2010). Cortical GABAergic Neurons: Stretching it Remarks, Main Conclusions and Discussion. Front Neuroanat. 2010 Mar 2;4:7.
DeFelipe J, Fields RD, Hof PR, Höistad M, Kostovic I, Meyer G, Rockland KS (2010). Cortical white matter: beyond the pale remarks, main conclusions and discussion. Front Neuroanat. 2010 Mar 24;4:4.
Ballesteros-Yáñez I, Benavides-Piccione R, Bourgeois JP, Changeux JP, DeFelipe J (2010) Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors. Proc Natl Acad Sci U S A. 107(25):11567-11572.
Garcia-Marin V, Blazquez-Llorca L, Rodriguez JR, Gonzalez J, DeFelipe J (2010) Differential distribution of neurons in the gyral white matter of the human cerebral cortex. J Comp Neurol 518:4740-459.
Blazquez-Llorca L, Garcia-Marin V, DeFelipe J (2010) GABAergic complex basket formations in the human neocortex. J Comp Neurol 518:4917-4937.
DeFelipe J (2010) From the connectome to the synaptome: an epic love history. Science 330(6008):1198-201.
DeFelipe J (2010) Cajal´s Butterflies of the Soul: Science and Art. Oxford University Press, New York).
DeFelipe J y Gonzáles F (coordinadores) (2010) El cerebro, la gran cepa azul. Arte y Neurociencia. Museo Elder. Las Palmas de Gran Canaria.
DeFelipe J, Jones EG. (2010) Neocortical Microcircuits. Handbook of Brain Microcircuits. (ed. Gordon Shepherd and Sten Grillner), Oxford University Press, New York.
DeFelipe J, (2010) The birth of modern neuroscience. In: Portraits of the Mind: Visualizing the Brain from Antiquity to the 21st Century. Schoonover CE (ed). Abrams, New York.
DeFelipe J (2010) Reflexiones sobre lo bello, el arte y la evolución del cerebro. En Neuroestética. Martín Araguz A (ed) Madrid. Saned, pp 51-76.
DeFelipe J (2010) Sobre lo bello, el arte y la ciencia: Paisajes neuronales. Coordinadores Javier de Felipe y Franck González. En: El cerebro, la gran cepa azul. Arte y Neurociencia. Museo Elder. Las Palmas de Gran Canaria, pp 33-72.
Morales, J., Alonso-Nanclares, L., Rodríguez, J., Merchán-Pérez, A., DeFelipe, J., and Rodríguez, Á. (2010). Computer Assisted Identification, Segmentation and Quantification of Synapses in the Cerebral Cortex. In Trends in Applied Intelligent Systems. Lecture Notes in Computer Science, N. García-Pedrajas, F. Herrera, C. Fyfe, J. M. Benítez, and M. Ali, eds. (Springer), pp. 112–118.
Kastanauskaite A, Alonso-Nanclares L, Blazquez-Llorca L, Pastor J, Sola RG, DeFelipe J (2009) Alterations of the microvascular network in sclerotic hippocampi from patients with epilepsy. J Neuropathol Exp Neurol. 68:939-950.
Garcia-Marin V, Blazquez-Llorca L, Rodriguez JR, Boluda S, Muntane G, Ferrer I, DeFelipe J (2009) Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques. Front Neuroanat. 3:28. Epub 2009 Nov 20.
Inda MC, DeFelipe J, Munoz A. (2009) Morphology and Distribution of Chandelier Cell Axon Terminals in the Mouse Cerebral Cortex and Claustroamygdaloid Complex. Cereb Cortex. 19(1):41-54.
Knafo S, Alonso-Nanclares L, J. Gonzalez-Soriano J, Merino-Serrais P, I. Fernaud-Espinosa1 I, Ferrer I, DeFelipe J (2009) Widespread changes in dendritic spines in a model of Alzheimer’s disease Cereb Cortex19(3):586-92.
Knafo S, Venero C, Merino-Serrais P, Fernaud-Espinosa I, Gonzalez-Soriano J, Ferrer I, Santpere G and DeFelipe J (2009) Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer’s disease. J. Pathol. 219:41-51.
Merchán-Pérez A, Rodriguez JR, Ribak CE, DeFelipe J (2009) Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9878-83. Epub 2009 Jun 1.
DeFelipe J (2009) Cajal y las mariposas del alma: plasticidad cerebral y procesos mentales. Ateneo (Madrid).
DeFelipe J (2009) Cajal's place in the history of neuroscience. Encyclopedia of Neuroscience. (L.R. Squire, Editor). Oxford: Academic Press. volume 2, pp. 497-507.
Ascoli G.A., Alonso-Nanclares L., Anderson S.A., Barrionuevo G., Benavides-Piccione R., Burkhalter A., Buzsaki G., Cauli B., DeFelipe J., Fairén A., Feldmeyer D., Fishell G., Fregnac Y., Freund T.F., Karube F., Gardner D., Gardner E.P., Goldberg J.H., Helmstaedter M., Hestrin S., Kisvarday Z., Lambolez B., Lewis D., Marin O., Markram H., Muñoz A., Packer A., Petersen C., Rockland K., Rossier J., Rudy B., Somogyi P., Staiger J.F., Tamas G., Thomson A.M., Toledo-Rodriguez M., Wang Y., West D.C., and Yuste R. (2008) PetillaTerminology: Nomenclature of features of GABAergic interneurons of the cerebral cortex. Nature Neuroscience 9:557-568.
Bote RP, Blázquez-Llorca L, Fernández-Gil MA, Alonso-Nanclares L, Muñoz A, De Felipe J. Hippocampal sclerosis: histopathology substrate and magnetic resonance imaging. Semin Ultrasound CT MR. 2008 Feb;29(1):2-14.
Ballesteros-Yanez I, Ambrosio E, Pérez J, Torres I; Miguéns M; García-Lecumberri C, DeFelipe J (2008) Morphine self-administration effects on the structure of cortical pyramidal cells in addiction-resistant rats. Brain Res 1230:61-72.
Alonso-Nanclares L, Gonzalez-Soriano J, Rodriguez JR, DeFelipe J (2008) Gender differences in human cortical synaptic density. Proc Natl Acad Sci USA. 105(38):14615-19. Epub 2008 Sep 8.
DeFelipe J. The Neuroanatomist's Dream, the Problems and Solutions, and the Ultimate Aim. Front Neurosci. 2008 Jul;2(1):10-2.
DeFelipe J (2008) Cajal, la teoría reticular y el neorreticularismo actual. Academia de Ciencias (Madrid).
Munoz A, Mendez P, Defelipe J, Alvarez-Leefmans FJ (2007) Cation-Chloride Cotransporters and GABA-ergic Innervation in the Human Epileptic Hippocampus. Epilepsia. 48:663-73.
Inda MC, Defelipe J, Munoz A. (2007) The Distribution of Chandelier Cell Axon Terminals that Express the GABA Plasma Membrane Transporter GAT-1 in the Human Neocortex. Cereb Cortex. 2006 Nov 10; [Epub ahead of print] .
Ballesteros-Yáñez I, Valverde O, Ledent C, Maldonado R, DeFelipe J (2007) Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1-dependent mechanism. Neuroscience 146:1536-1545.
Arellano JI, Espinosa A, Fairen A, Yuste R, Defelipe J (2007) Non-synaptic dendritic spines in neocortex. Neuroscience 145:464-469.
Benavides-Piccione R, DeFelipe J. (2007) Distribution of neurons expressing tyrosine hydroxylase in the human cerebral cortex. J Anat. 211:212-222.
Muñoz A, DeFelipe J (2007) Cell specificity of altered cation-chloride cotransporter expression and GABAergic innervation in the epileptic cerebral cortex. Future Neurology 2: 383-387.
Arellano JI, Benavides-Piccione R, DeFelipe J, Rafael Yuste R (2007) Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies. Frontiers in Neuroscience 1: 131-143.
Andrioli A, Alonso-Nanclares L, Arellano JI, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience. 2007 Oct 12;149(1):131-43.
DeFelipe J, Fernández-Gil MA, Kastanauskaite A, Bote RP, Presmanes YG, Ruiz MT (2007) Macroanatomy and microanatomy of the temporal lobe. Semin Ultrasound CT MR. 2007 Dec;28(6):404-15.
García-Segura LM, DeFelipe, J. (2007) Los dibujos de Cajal. En: Santiago Ramón y Cajal. Premio Nobel 1906. Sociedad Estatal de Conmemoraciones Culturales, Madrid. Santarén JF (ed.) pp: 261-260.
DeFelipe, J (2007) Cajal y la neurociencia del siglo XXI. En: DeFelipe J, Markram H y Wagensberg J (Coordinadores) Paisajes Neuronales:Homenaje a Santiago Ramón y Cajal. Consejo Superior de Investigaciones Científicas e Instituto Cervantes. Madrid, pp: 41-97.
DeFelipe, J (2007) Santiago Ramón y Cajal, el padre de la neurociencia moderna. En: Actas Congreso Cajal. Gobierno de Aragón. Zaragoza, pp: 462-483.
DeFelipe J, Alonso-Nanclares L, Arellano J, Ballesteros-Yáñez I, Benavides-Piccione R, Munoz A (2007). Specializations of the cortical microstructure of humans. In: Evolution of the nervous systems: a comprehensive reference. Vol. 4. Primates. Kaas, J. H. & Preuss, T. M. (eds.). Amsterdam, Elsevier, 2007. pp: 167-190.
DeFelipe, J. (2007) Historia de la neurona: influencia de los estudios de Santiago Ramón y Cajal en la neurociencia moderna. En: Histología del sistema nervioso del hombre y de los vertebrados. Santiago Ramón y Cajal. Ministerio de Sanidad y Consumo, Consejo Superior de Investigaciones Científicas y Boletín Oficial del Estado. Madrid, pp: 19-99.
DeFelipe J. (2006) Brain plasticity and mental processes: Cajal again. Nat Rev Neurosci. 7:811-817.
Ballesteros-Yanez I, Ambrosio E, Benavides-Piccione R, Perez J, Torres I, Miguens M, García-Lecumberri C, DeFelipe J (2007). The effects of morphine self-administration on cortical pyramidal cell structure in addiction-prone lewis rats. Cereb Cortex. 2007 1:238-49.
Benavides-Piccione R, Hamzei-Sichani F, Ballesteros-Yañez I, DeFelipe J, Yuste R (2006) Dendritic size of pyramidal neurons differs among mouse cortical regions. Cerebral Cortex 16:990-1001.
Ballesteros-Yáñez I, Benavides-Piccione R, Elston GN, Yuste R and DeFelipe J. (2006) Density and morphology of dendriticspines in mouse neocortex. Neuroscience 138:403-409.
Yague JG, Muñoz A, Monasterio-Schrader P, DeFelipe J, García-Segura LM, Azcoitia I. (2006) Aromatase expression in the human temporal cortex. Neuroscience 138:389-401.
Arion D, Sabatini M, Unger T, Pastor J; Alonso-Nanclares L, Ballesteros-Yáñez I, García Sola R, Muñoz A, DeFelipe J (2006) Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy. Neurobiology of Disease 22:374-387.
DeFelipe J, Alonso-Nanclares L, Blatow M, Caputi A, Monyer H (2006). Anatomical and molecular heterogeneity of cortical GABAergic interneurons. En: “Microcircuits: The Interface between Neurons and Global Brain Function. Dahlem Workshop Report 93”. Editor: S. Grillner and A. M.Graybiel. Cambridge, MA: The MIT Press, pp 295-325.
DeFelipe J, I. Ballesteros, M.C.Inda, A. Muñoz (2006) Distribution of double bouquet cells in the primary and secondary visual cortex in the human and macaque monkey. Visual Perception. Susana Martínez-Conde, Stephen L. Macknik, Luis M. Martínez, Jose-Manuel Alonso, Peter U. Tse. Eds. Prog. Brain Res. 154:15-32.
DeFelipe, J. (2006) Cajal y sus dibujos: Ciencia y arte. En: Arte y Neurología (Martín-Araguz, A). pp: 213-230. Saned: Madrid.
DeFelipe, J. (2006) Santiago Ramón y Cajal y el nacimiento de la neurociencia moderna. Ramón y Cajal y la Ciencia Española. Instituto Superior de Formación del Profesorado. Ministerio de Educación y Ciencia, pp: 9-32.
DeFelipe, J. (2006) Cajal y la plasticidad cerebral. En: Santiago Ramón y Cajal (Cien años después" Antoni Gamundí y Alberto Ferrús (Coordinadores) Editorial Pirámide - Universitat de les Illes Balears, pp: 257-272.
Inda MC, DeFelipe J, Muñoz A (2006) Voltage-Gated Ion Channels in the Axon Initial Segment of human Cortical Pyramidal Cells and Their Relationship with Chandelier Cells. PNAS 103: 2920-2925.
Alonso-Nanclares L., Garbelli R., Sola R.G., Pastor J., Tassi L., Spreafico R. and DeFelipe J. (2005). Microanatomy of the dysplastic neocortex from epileptic patients. Brain. 128:158-173.
Benavides-Piccione R., Arellano J.I. and Javier DeFelipe J. (2005). Catecholaminergic innervation of pyramidal neurons in the human temporal cortex. Cerebral Cortex. 15:1584-1592.
Ballesteros-Yánez I., Muñoz A., Contreras J., Gonzalez J., Rodriguez-Veiga E. and DeFelipe J. (2005). The double bouquet cell in the human cerebral cortex and a comparison with other mammals. J. Comp. Neurol. 486:344-360.
Benavides-Piccione R., Dierssen M., Ballesteros-Yañez, I., Martínez de Lagran M., Arbones M.L., Fotaki V., DeFelipe J. and Elston G.N. (2005). Alterations in the phenotype of neocortical pyramidal cells in the dyrk1a +/- mouse. Neurobiology of Disease. 74:111-126.
Sola R.G. , Hernando-Requejo V., Pastor J., García-Navarrete E., DeFelipe J., Alijarde M.T., Sánchez A., Domínguez-Gadea L., Martín-Plasencia P., Maestú F., DeFelipe-Oroquieta J., Ramón-Cajal S. and Pulido-Rivas P. (2005). Epilepsia farmacorresistente del lóbulo temporal. Exploración con electrodos del foramen oval y resultados quirúrgicos. Rev. Neurol. 41:4-16.
Alonso-Nanclares L. and DeFelipe J. (2005). Vesicular glutamate transporte 1 immunostaining in the normal and apileptic human cerebral cortex. Neuroscience. 134: 59-68.
Elston G.N., Benavides-Piccione R., Elston A., Manger P. and DeFelipe J. (2005). Pyramidal cell specialization in the occipitotemporal cortex of the vervet monkey. Neuroreport. 16: 967-970.
Elston G.N., Benavides-Piccione R., Elston A., DeFelipe J. and Manger P. (2005). Pyramidal cell specialization in the occipitotemporal cortex of the chacma baboon (Papio ursinus). Experimental Brain Research. 167: 496-503.
Elston G.N., Benavides-Piccione R., Elston A., Manger P. and DeFelipe J. (2005). Regional specialization in pyramidal cell structure in the limbic cortex of the vervet monkey (Cercopithecus pygerythrus): an intracellular injection study of the anterior and posterior cingulate gyrus. Experimental Brain Research. 167:315-323.
Elston G.N., Benavides-Piccione R., Elston A., DeFelipe J. and Manger P. (2005). Specialization in pyramidal cell structure in the sensory-motor cortex of the vervet monkey (Cercopethicus pygerythrus). Neuroscience. 134: 1057-1068 .
Elston G.N., Benavides-Piccione R., Elston A., Manger P. and DeFelipe J. (2005). Specialization in pyramidal cell structure in the sensory-motor cortex of the chacma baboon (papio ursinus) with comparative notes on the macaque and vervet monkeys. Anat. Rec. A. Discov. Mol. Cell. Evol. Biol. 286:854-865.
Elston G.N., Benavides-Piccione R., Elston A., DeFelipe J. and Manger P. (2005). Specialization in pyramidal cell structure in the cingulate cortex of the chacma baboon (Papio ursinus): An intracellular injection study of the posterior and anterior cingulate gyrus with comparative notes on the macaque and vervet monkeys. Neuroscience Letters. 387: 130-135.
DeFelipe J (2005) Reflections on the structure of the cortical minicolumn. In Neocortical modularity and the cell minicolumn (M.F. Casanova, ed.) Nova Science Publishers, New York. Pp: 57-91.
Elston G.N., Benavides-Piccione R. and Defelipe J. (2004). A study of pyramidal cell structure in the cingulate cortex of the macaque monkey with comparative notes on inferotemporal and primary visual cortex. Cerebral Cortex. 15:64-73.
Benavides-Piccione R., Hamzei-Sichani F., Ballesteros-Yañez I., DeFelipe J.and Yuste R. (2005). Dendritic size of pyramidal neurons differs among mouse cortical regions. Cerebral Cortex (in press).
Ballesteros-Yáñez I., Benavides-Piccione R., Elston G.N., Yuste R. and Javier DeFelipe J. Density and morphology of dendritic spines in mouse neocortex. Neuroscience (en prensa).
Yague J.G., Muñoz A., Monasterio-Schrader P., DeFelipe J., García-Segura L.M. and Azcoitia I. Aromatase expression in the human temporal cortex. Neuroscience (en prensa).
Arellano J.I., Muñoz A., Ballesteros-Yáñez I., Sola R.G. and DeFelipe J. (2004). Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain. 127: 45-64.
Alonso-Nanclares L., White E.L., Elston G.N. and DeFelipe J. (2004). Synaptology of the proximal segment of pyramidal cell basal dendrites. Eur J. Neurosci. 19:771-776.
Alonso-Nanclares L., Minelli A., Melone M., Quagliano F., Reimer R.J., Edwards R.H., DeFelipe J. and Conti F. (2004). Perisomatic glutamatergic axon terminals: A novel feature of cortical synaptology revealed by vesicular glutamate transporter 1 immunostaining. Neuroscience. 123:547-556.
DeFelipe J. (2004). Forum: Cortical microanatomy and human brain disorders: Epilepsy. Cortex. 40:232-233.
Velez-Pardo C., Arellano J.I., Cardona-Gomez P., Jimenez- Del Rio M., Francisco Lopera F. and DeFelipe J. (2004). CA1 hippocampal neuronal loss in Familial Alzheimer’s disease presenilin-1 E280A mutation is related with epilepsy. Epilepsia. 45:751-756.
Benavides-Piccione R., Ballesteros-Yáñez I., Martínez de Legrán M., Elston G., Estivill X., Fillat C., DeFelipe J. and Dierssen M., (2004). On dendrites in Down syndrome and DS murine models:a spiny way to learn. Progress Neurobiol. 74:111-126.

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