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Departamentos > Neurobiología Molecular, Celular y del Desarrollo > Bases moleculares de la memoria, la neurodegeneración y la biocatálisis > Publicaciones

Investigación Personal Publicaciones Otros

Publicaciones

  • Vera, A., Galera-Prat, A., Wojciechowski, M., Rozycki, B., Laurents, D.V. and Carrión-Vázquez, M. and Tinnefeld, P. (2020). Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization. bioRxiv doi:10.1101/2019.12.19.882373.
  • Fernández-Ramírez, M.C., Hervás, R., Menéndez, M., Laurents, D.V. and Carrión-Vázquez M. (2020). Tau amyloidogenesis begins with a loss of its conformational polymorphism. bioRxiv doi: 10.1101/2020.06.18.158923. En revisión en Science Advances.
  • López-García, P., Ramírez de Mingo, D., McGreevy, K.R., Santi, A., Laurents D.V., Nagai, Y., Trejo, J.L., and Carrión-Vázquez M. (2020). An anti-amyloidogenic treatment to specifically block the consolidation of traumatic events in mouse. bioRxiv doi: 10.1101/2020.01.21.913053.
  • Ramírez de Mingo D, Hervás, R., Pantoja-Uceda D, Carrión-Vázquez, M. Laurents DV (2020). Preferred conformations in the intrinsically disordered region of human CPEB3 explain its role in memory consolidation. bioRxiv doi:10.1101/2020.05.12.091587. En revisión en Nature Communications.
  • Ramírez de Mingo D., López-García, P., Hervás, R., Laurents D.V., and Carrión-Vázquez M. (2020). Molecular determinants of liquid demixing and amyloidogenesis in human CPEB3. bioRxiv doi: 10.1101/2020.06.02.129783. En revisión en Nature Communications.
  • Hervás, R., Fernández-Ramírez, M.C., Galera-Prat, A., Suzuki, M., Nagai, Y., Bruix, M., Menéndez, M., Laurents, D.V., and Carrión-Vázquez, M. (2020). Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold. bioRxiv. DOI:10.1101/2020.05.19.103804.
  • Galera-Prat, A., Vera, A.M., Moraïs, S. Vazana, Y., Bayer, E.A. and Carrión-Vázquez, M. (2020). Impact of scaffoldin mechanostability on cellulosomal activity. Biomat. Sci, 8, 3601-3610 DOI: 10.1039/C9BM02052G. Portada de la revista.
  • Mompeán M, Ramírez de Mingo D, Hervás R, Fernández-Ramírez MDC, Carrión-Vázquez, M. and Laurents DV. (2019). Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1. Arch. Biochem. Biophys. 675: 1081133. doi: 10.1016/j.abb.2019.108113.
  • Barruetabeña, N. Alonso-Lerma, B. Galera-Prat, A. Joudeh, N., Barandiaran, L., Aldazabal, l., Garcia-Parra, P. Marie Fertin, P., Manteca, A. Rodriguez-Couto, S., Arbulu, M., De Sancho, D., Alcalde, M., Carrión-Vázquez, M. & Perez-Jimenez, R. (2019). Resurrection of efficient Precambrian endoglucanases for lignocellulosic biomass hydrolysis. Communications Chemistry 2, 76. DOI: 10.1038/s42004-019-0176-6.
  • Oroz J, Galera-Prat A, Hervás R, Valbuena A, Fernández-Bravo D, Carrión-Vázquez M. (2019). Nanomechanics of tip-link cadherins. Sci. Rep. 9(1):13306. doi: 10.1038/s41598-019-49518-x.
  • Galera-Prat A, Moraïs S, Vazana Y, Bayer EA, Carrión-Vázquez, M. (2018). The cohesin module is a major determinant of cellulosome mechanical stability. J Biol Chem. pii: jbc.RA117.000644. doi: 10.1074/jbc.RA117.000644.
  • Galera-Prat A, Pantoja-Uceda D, Laurents DV, Carrión-Vázquez, M.. (2018). Solution conformation of a cohesin module and its scaffoldin linker from a prototypical cellulosome. Arch. Biochem. Biophys. 644:1-7. doi: 10.1016/j.abb.2018.02.016.
  • Chwastyk M, Vera AM, Galera-Prat A, Gunnoo M, Thompson D, Carrión-Vázquez, M., Cieplak M. (2017). Non-local effects of point mutations on the stability of a protein module. J. Chem. Phys.147:105101. doi: 10.1063/1.4999703.
  • Vera, A. and Carrión-Vázquez, M. (2016). Direct identification of protein-protein interactions in single-molecule force spectroscopy. Angew. Chem. 10.1002/anie.201605284R2 and 10.1002/ange.201605284R2.
  • Wojciechowski, M. Gómez-Sicilia, À., Carrión-Vázquez, M. & Cieplak, M. (2016). Unfolding knots by proteasome-like systems: simulations of the behaviour of folded and neurotoxic proteins. Mol. Biosyst. doi: 10.1039/C6MB00214E.
  • Oroz, J., Bruix, M. Laurents, D., Galera-Prat, A., Schönfelder, J., Cañada, F.J., and Carrión-Vázquez, M. (2016). The titin Y9P variant of the titin I27 module: structural determinants of its revisited nanomechanics. Structure 24, 1-11. doi:10.1016/j.str.2016.02.016.
  • *Hervás, R., Li, L., Majundar, A., Fernández-Ramírez, M.C., Unruh, J.R., Slaughter, B.D., Galera-Prat, A., Santana, E., Suzuki, M., Nagai, Y., Bruix, M., Casas-Tintó, S., Menéndez, M., Laurents, D.V., Si, K., and Carrión-Vázquez, M. (2016) Molecular basis of Orb2 amyloidogenesis and blockade of memory consolidation. PLoS Biology 14(1):e1002361. doi: 10.1371/journal.pbio.1002361. Comentario en: Roberts, R.G. (2016). Good Amyloid, Bad Amyloid –What’s the Difference? PLoS Biol. 14(1): e1002362. doi:10.1371/journal.pbio.1002362
  • Gunnoo. M., Cazade, P.-A., Galera-Prat, A., Nash, M.A., Czjzek, M., Cieplak, M., Alvarez, B., Aguiar, M., Karpol, A., Gaub, H., Carrión-Vázquez, M., Bayer, E.A., & Thompson, D. (2016). Nano-scale engineering of designer cellulosomes. Adv. Mater. DOI: 10.1002/adma.201503948.
  • Gómez-Sicilia, A., Sikora, M., Cieplak, M. and Carrión-Vázquez, M. (2015). An exploration of the universe of polyglutamine structures. PLoS Comp. Biol. 11(10):e1004541. doi: 10.1371/journal.pcbi.1004541.
  • Méndez-Gómez, H.R., Galera-Prat, A., Meyers, C., Chen W, Carrión-Vázquez, M. and Muzyczka, N. (2015). Transcytosis in the blood-cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system. Mol Ther Methods Clin Dev. 2:15037. doi: 10.1038/mtm.2015.37.
  • Mompeán, M., Hervás, R., Xu, Y., Tran, T., Guarnaccia, C., Buratti, E., Baralle, F.,Tong, L., Carrión-Vázquez, M., McDermott, A. & Laurents, D.V. (2015). Structural evidence of Amyloid Fibril Formation in the putative aggregation domain of TDP-43. J. Chem. Phys. Lett. 6:2608-15. doi: 10.1021/acs.jpclett.5b00918.
  • Ramos-Martín, F., Hervás, R., Carrión-Vázquez, M. & Laurents, D.V. (2014). NMR spectroscopy reveals that polyglutamine binding peptide 1 adopts a preferred conformation with a defined hydrophobic cluster. Arch. Biochem. Biophys. 558:104-110.
  • Wojciechowski, M., Szymczak, P., Carrión-Vázquez, M., and Cieplak, M. (2014). Protein unfolding by biological unfoldases: insights from modeling. Biophys. J. 107:1661-1668.
  • de Pablo P.J. and Carrión-Vázquez, M. (2014). Imaging biological samples with atomic force microscopy. Cold Spring Harb. Protoc.. 2014:167-177. doi: 10.1101/pdb.top080473.
  • Chwastyk, M., Galera–Prat, A., Sikora, M., Gómez-Sicilia, À., Carrión-Vázquez, M. and Cieplak, M. (2014). Theoretical tests of the mechanical protection strategy in protein nanomechanics. Proteins. 82: 717. doi: 10.1002/prot.24436.
  • Valbuena A., Vera, A.M., Oroz, J. and Carrión-Vázquez, M. (2012). Mechanical properties of β-catenin revealed by single-molecule techniques. Biophys. J. 103:1744-1752.
  • Oroz J., Valbuena A., Hervás, R. & Carrión-Vázquez, M. (2012). Unequivocal single-molecule force spectroscopy of intrinsically disordered proteins. Methods Mol. Biol. 896:71-87.
  • *Hervás, R., Oroz J., Galera-Prat, A., Goñi, O., Valbuena A., Vera, A.M., Gómez-Sicilia, A., Losada-Urzáiz, F., Uversky, V.N., Menéndez, M., Laurents, D. Bruix, M. and Carrión-Vázquez, M. (2012). Common features at the start of the neurodegeneration cascade. PLoS Biology 102:682-690. 10:e1001335. doi: 10.1371/journal.pbio.1001335. Comentario en: Weaver J. (2012). Single-molecule technique links structural fluctuations of proteins to brain diseases. PLoS Biology DOI: 10.1371/journal.pbio.1001338.
  • Oroz J., Hervás, R. and Carrión-Vázquez, M.(2012). Unequivocal single-molecule force spectroscopy of proteins by AFM using pFS vectors. Biophys. J. 102: 682-690.
  • Oroz J., Valbuena A., Vera, A.M., Mendieta, J. Gómez-Puertas, P., and Carrión-Vázquez, M. (2011). Nanomechanics of the cadherin ectodomain: “canalization” by Ca2+ binding results in a new mechanical element. J. Biol. Chem. 286:9405-9418.
  • Galera-Prat, A., Gómez-Sicilia, A., Oberhauser A.F, Cieplak, M. & Carrión-Vázquez, M. (2010). Understanding biology by stretching proteins: recent progress. Curr. Opin. Str. Biol. 20: 63-69.
  • *Valbuena A., Oroz J., Hervás, R., Vera, A.M., Rodriguez, D., Menéndez, M., Sulkowska,J.I., Cieplak, M. and Carrión-Vázquez, M. (2009). On the remarkable mechanostability of scaffoldins and the mechanical clamp motif. Proc. Natl. Acad. Sci USA 106:13791-13796.
  • Oberhauser, A.F, and Carrión-Vázquez, M. (2008). Mechanical biochemistry of proteins one molecule at a time. J. Biol. Chem. 283, 6617-6621.
  • Valbuena A., Oroz J., Vera, A.M., Gimeno, A., Gómez-Herrero, J. and Carrión-Vázquez, M. (2007). Quasi-simultaneous imaging/pulling analysis of polyprotein molecules by AFM. Rev. Sci. Instrum. 78, 113707.
  • Ainavarapu, S.R.K., Brujic J., Huang, H.H., Wiita, A.P., Lu, H., Li, L., Walther, K.A., Carrión-Vázquez, M., Li, H., and J. M. Fernandez (2007). Contour length and refolding rate of a small protein controlled by engineered disulfide bonds. Biophys. J. 92, 225-233.
  • *Carrión-Vázquez, M., Li, H., Lu, H.,Marszalek, P.E., Oberhauser A.F. and J.M. Fernández (2003). The mechanical stability of ubiquitin is linkage dependent. Nature Str. Biol. 10, 738-743.
  • Li, H., Linke, W. A., Oberhauser, A.F., Carrión-Vázquez, M., Kerkvliet, J.G., Lu, H., Marszalek, P.E., and J.M. Fernández (2002). Reverse engineering of the giant muscle protein titin. Nature 418,998-1002.
  • Oberhauser, A.F., Badilla-Fernández, C., Carrión-Vázquez, M., and J.M. Fernández (2002). The mechanical hierarchies of fibronectin observed with single-molecule AFM. J. Mol. Biol. 319, 433-447.
  • Li, H., Oberhauser, A.F., Redick, S., Carrión-Vázquez, M., Erickson, H.P., and J.M. Fernández (2001). Multiple conformations of PEVK proteins detected by single-molecule techniques. Proc. Natl. Acad. Sci USA 98, 10682-10686.
  • Oberhauser, A.F., Hansma, P. Carrión-Vázquez, M., and J.M. Fernández (2001). Stepwise unfolding events in titin under the force-clamp AFM. Proc. Natl. Acad. Sci USA. 98,468-472.
  • Carrión-Vázquez, M., Oberhauser, A.F., Fisher, T.E., Marszalek, P.E., Li, H. and J.M. Fernández (2000). Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. Prog. in Biophys. Mol. Biol. 74, 63-91.
  • Li, H., Carrión-Vázquez, M., Oberhauser, A.F., Marszalek, P.E., and J.M. Fernández (2000). Point mutations alter the mechanical stability of immunoglobulin modules. Nature Struct. Biol. 7, 1117-1120.
  • Fisher, T.E., Carrión-Vázquez, M. and J.M. Fernández (2000). Intracellular Ca2+ channel immunoreactivity in neuroendocrine axon terminals. FEBS Lett. 482,131-138.
  • Fisher, T.E., Carrión-Vázquez, M., Oberhauser, A.F., Marszalek, P.E., Li, H. and J.M. Fernández (2000). Single molecule force spectroscopy of modular proteins in the nervous system. Neuron 27, 435-446.
  • Carrión-Vázquez, M., Oberhauser, A.F., Marszalek, P.E., and J.M. Fernández (1999). Atomic force microscopy captures length phenotypes in single proteins. Proc. Natl. Acad. Sci. USA 96, 11288-11292.
  • Fisher, T.E., Oberhauser, A.F., Carrión-Vázquez, M., Marszalek, P.E., and J.M. Fernández (1999). The study of protein mechanics with the atomic force microscope. Trends in Biochem. Sci. 24,379-384.
  • Fisher, T.E., Marszalek, P.E, Oberhauser, A.F., Carrión-Vázquez, M., and J.M. Fernández (1999). The micro-mechanics of single molecules studied with atomic force microscopy. J. Physiol. (Lond.) 520, 5-14.
  • Oberhauser, A.F., Marszalek, P.E., Carrión-Vázquez, M., and J.M. Fernández (1999). Single protein misfolding events captured by AFM. Nature Str. Biol. 6, 1025-1028.
  • *Carrión-Vázquez, M., Oberhauser, A.F., Fowler, S.B., Marszalek, P.E., Broedel, S.E., Clarke, J. and J.M. Fernández (1999). Mechanical and chemical unfolding of a single protein: a comparison. Proc. Natl. Acad. Sci. USA 96, 3694-3699.
  • Marszalek, P.E., Lu, H., Li, H., Carrión-Vázquez, M., Oberhauser, A.F., Schulten K., and J.M. Fernández (1999). Mechanical unfolding intermediates in titin modules. Nature 402, 100-103.
  • Carrión-Vázquez, M., Fernández, A. M., Chowen, J M. & M. Nieto-Sampedro (1998). Brain Ac39/physophilin: cloning, coexpression and colocalization with synaptophysin. Eur. J. Neurosci. 10, 1153-1166.
  • Robinson, I., Yamada, M., Carrión-Vázquez, M., Lennon, V., and J. M. Fernández (1996). Specialized release zones in chromaffin cells examined with pulsed-laser imaging. Cell Calcium 20(2), 181-201.

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