Stem cells, neurogenesis and neurodegeneration

See full list at www.gasconlab.com

Patents:

Gascón S and Götz M. Trans-differentiation of differentiated cells. European patent application for anti-oxidant molecules in direct neuronal reprogramming, WO 2015/114059 A1. 2015.

Book Chapters:

Amel Falco, Rocío Bartolomé-Cabrero, Sergio Gascónɸ§. Bcl-2-assisted Reprogramming of Mouse Astrocytes and Human Fibroblasts into Induced Neurons. Methods in Molecular Biology - Springer Nature. In press.

Reviews:

Amel Falco, Rocío Bartolomé-Cabrero, Sergio Gascónɸ§. Bcl-2-assisted Reprogramming of Mouse Astrocytes and Human Fibroblasts into Induced Neurons. Methods in Molecular Biology - Springer Nature. In press.
Stockwell BR, Friedmann Angeli JP, Bayir H, Bush A, Conrad M, Dixon S, Fulda S, Gascón S, Hatzios S, Kagan V, Noel K, Jiang X, Linkermann A, Murphy M, Overholtzer M, Oyagi A, Pagnussat G, Park J, Prives C, Ran Q, Rosenfeld C, Salnikow K, Tang D, Torti F, Torti S, Toyokuni S, Woerpel K, Zhang D. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 2017. Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021.
Gascón S*, Masserdotti G*, Russo G*, Götz M. Direct neuronal reprogramming – achievements, hurdles and new roads to success. Cell Stem Cell. 2017 Jul 6;21(1):18-34. doi: 10.1016/j.stem.2017.06.011.
Masserdotti G*, Gascón S*, Götz M. Direct neuronal reprogramming-Learning from and for development. Development. 2016 143: 2494-2510; doi: 10.1242/dev.092163.

Original articles:

Karakatsani A, Marichal N*, Urban, S*, Kalamakis G, Schick A, Zhang Y, Ghanem A, Zhang, Y., Conzelmann K, Rüegg MA, Berninger B, Ruiz de Almodovar C, Gascón S§ɸ, Kröger Sɸ§. Neuronal LRP4 Regulates Synapse Formation in the Developing CNS. Development. 2017 Oct 23. pii: dev.150110. doi: 10.1242/dev.150110.
Miyakoshi L, Peron S, Brill M, Ortega F, Gascón S§, Berninger B§. Programming of neural progenitors of the adult subependymal zone towards a glutamatergic identity by Neurog2. Development. In minor revision.
Pdf access at: http://www.biorxiv.org/content/early/2017/08/03/171686.full.pdf+html
Murenu E, Bressan C, Petrik D, Ohlig S, Cernilogar F, Thorwirth M, Schotta G, Vidal M, Saghatelyan A, Götz M§, Gascón Sɸ§. Ring1B as novel regulator of migration and dendrite development in adult neurogenesis. PLoS Genetics. In revision.
Gómez-Villafuertes R*, Paniagua-Herranz L*, Gascón S*, Agustín-Durán D, Ferreras M, Gil-Redondo JC, Queipo MJ, Menendez-Mendez A, Pérez-Sen R, Delicado EG, Gualix J, Costa MR, Schroeder T, Miras-Portugal MT, Ortega F. Live imaging followed by single cell tracking to monitor cell biology and the lineage progression of multiple neural populations. J Vis Exp. 2017 Dec 16;(130). doi: 10.3791/56291.
Gascón Sɸ, Ortega F, Götz Mɸ. Transient CREB-mediated transcription is key in direct neuronal reprogramming. Neurogenesis. 2017 Feb 6;4(1):e1285383. doi: 10.1080/23262133.2017.1285383.
Gascón Sɸ*, Murenu E*, Masserdotti G, Ortega F, Russo G, Petrik D, Deshpande A, Heinrich C, Karow M, Robertson S, Schroeder, Beckers J, Irmler M, Berndt C, Friedmann JP, Conrad M, Berninger B, Götz Mɸ. Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming. Cell Stem Cell. 2016 Mar 3;18(3):396-409. doi: 10.1016/j.stem.2015.12.003
This work has been highlighted by F1000Prime as being of special significance in its field.https://f1000.com/prime/726066295?subscriptioncode=3248f6ce-490a-498d-963a-b4374a3300a9 [See also Previews, by Quadrato G, Zhang AC, Arlotta P (2016) Stressed out? Healing tips for newly reprogrammed neurons, Cell Stem Cell 18: 297-299].
Sirko, S, Irmler M, Gascón S, Bek S, Schneider S, Dimou L, Obermann J, De Souza Paiva D, Poirier F, Beckers J, Hauck SM, Barde YA, Götz M. Astrocyte reactivity after brain injury: The role of galectins 1 and 3. Glia. 2015 Dec;63(12):2340-61. doi: 10.1002/glia.22898
Faiz M, Sachewsky N, Gascón S, Bang KW, Morshead CM, Nagy A. Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke. Cell Stem Cell. 2015 Nov 5;17(5):624-34. doi: 10.1016/j.stem.2015.08.002
Heinrich C*, Bergami M*, Gascón S, Lepier A, Viganò F, Dimou L, Sutor B, Berninger B, Götz M. Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports. 2014 Dec 9;3(6):1000-14. doi: 10.1016/j.stemcr.2014.10.007
Ortega F, Gascón S*, Masserdotti G*, Deshpande A, Simon C, Dimou L, Lie C, Schroeder T, Berninger B. Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling. Nature Cell Biology. 2013 Jun;15(6):602-13. doi: 10.1038/ncb2736
Karow M*, Sánchez R*, Schichor, C, Masserdotti G, Ortega F, Heinrich C, Gascón S, Kahn A, Lie C, Dellavalle A, Cossu G, Goldb-runner R, Götz M, Berninger B. Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell. 2012 Oct 5;11(4):471-6. doi: 10.1016/j.stem.2012.07.007
Vidaurre OG*, Gascón S*, Deogracias R, Sobrado M, Cuadrado E, Montaner J, Rodríguez-Peña A, Diaz-Guerra M. Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity. Cell Death & Disease. 2012 Jan 19;3:e256. doi: 10.1038/cddis.2011.143
Heinrich C, Gascón S, Masserdotti G, Lepier A, Sanchez R, Simon-Ebert T, Schroeder T, Götz M, Berninger B. Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex. Nature Protocols. 2011 Feb;6(2):214-28. doi: 10.1038/nprot.2010.188
Heinrich C, Blum R*, Gascón S*, Masserdotti G*, Tripathi P, Sánchez R, Tiedt S, Schroeder T, Götz M, Berninger B. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biology. 2010 May 18;8(5):e1000373. doi: 10.1371/journal.pbio.1000373
Brill MS*, Ninkovic J*, Winpenny E*, Hodge RD*, Ozen I, Yang R, Lepier A, Gascón S, Erdelyi F, Szabo G, Parras C, Guillemot F, Frotscher M, Berninger B, Hevner RF, Raineteau O, Götz M. Adult generation of glutamatergic olfactory bulb interneurons. Nature Neuroscience. 2009 Dec;12(12):1524-33. doi: 10.1038/nn.2416
López-Menéndez C, Gascón S, Sobrado M, Vidaurre OG, Higuero AM, Rodríguez-Peña A, Iglesias T, Díaz-Guerra M. Kidins220/ARMS downregulation by excitotoxic activation of NMDARs reveals its involvement in neuronal survival and death pathways. Journal of Cell Science. 2009 Oct 1;122(Pt 19):3554-65. doi: 10.1242/jcs.056473
Gascón S, Paez-Gomez JA, Díaz-Guerra M, Scheiffele P, Scholl FG. Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons. Journal of Neuroscience Methods. 2008 Feb 15;168(1):104-12. doi: 10.1016/j.jneumeth.2007.09.023
Gascón S, Sobrado M, Roda JM, Rodríguez-Peña A, Díaz-Guerra M. Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95. Molecular Psychiatry. 2008 Jan;13(1):99-114. We provided the cover in this issue. doi: 10.1038/sj.mp.4002017
Gascón S*, García-Gallo M*, Renart J, Díaz-Guerra M. Endoplasmic reticulum-associated degradation of the NR1 but not the NR2 subunits of the N-methyl-D-aspartate receptor induced by inhibition of the N-glycosylation in cortical neurons. Journal of Neuroscience Research. 2007 Jun;85(8):1713-23. doi: 10.1002/jnr.21309
Gascón S, Deogracias R, Sobrado M, Roda JM, Renart J, Rodríguez-Peña A, Díaz-Guerra M. Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia. The Journal of Biological Chemistry. 2005 Oct 14;280(41):35018-27. doi: 10.1074/jbc.M504108200

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