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Research Departments > Department of Translational Neuroscience > Neuropharmacology > Publications

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Publications

  • Ballesta, J., Cremades, J., Rodríguez-Muñoz, M., Garzón, J., Faura, C.: “Sensitivity to µ opioid receptor-mediated antinociception is determined by cross-regulation between µ and δ opioid receptors at supraspinal level” Br J Pharmacol doi: 10.1111/j.1476-5381.2011.01750.x (2011). PMID: 22023056.

  • Alba-Delgado, C., Borges, G., Sánchez-Blázquez, P., Ortega, J.E., Horrillo, I., Micó, J.A., Meana, J., Neto, F., Berrocoso, E.: “The function of alpha-2-2adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain” Psychopharmacology doi: 10.1007/s00213-011-2542-7 (2011). PMID: 22038538.

  • Garzón, J., Rodríguez-Muñoz, M., Vicente-Sánchez, A., García-López, MA., Martínez-Murillo, R., Fischer, T., Sánchez-Blázquez, P.: “SUMO-SIM interactions regulate the activity of RGSZ2 proteins” PlosOne 6(12): e28557 (2011). PMID: 22163035.

  • M. Rivera-Alba, S. N. Vitaladevuni, Y. Mischenko, Z. Lu, S. Takemura, L. Scheffer, I. A. Meinertzhagen, D. B. Chklovskii & G.G. de Polavieja, 'Wiring economy and volume exclusion determine neuronal placement in the Drosophila brain', Current Biology 21, 2000 (2011).

  • RODRÍGUEZ-MUÑOZ, M., SÁNCHEZ-BLÁZQUEZ, P., VICENTE-SÁNCHEZ, A., BAILÓN, C., MARTÍN-AZNAR, B., GARZÓN, J.: “The histidine triad nucleotide binding protein 1 supports Mu-opioid receptor-glutamate NMDA receptor cross-regulation” Cell & Mol Life Sci 68, 2933-2949 (2011). PMID: 21153910.

  • RODRÍGUEZ-MUÑOZ, M., SÁNCHEZ-BLÁZQUEZ, P., VICENTE-SÁNCHEZ, A., BERROCOSO, E., y GARZÓN, J.: “The Mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control” Neuropsychopharmacology doi:10.1038/npp.2011.155 (2011). PMID: 21814188.

  • GARZÓN, J., RODRÍGUEZ-MUÑOZ, M., VICENTE-SÁNCHEZ, A., BAILÓN, C., MARTÍNEZ-MURILLO, R., SÁNCHEZ-BLÁZQUEZ, P.: “RGSZ2 binds to the nNOS PDZ domain to regulate Mu-opioid receptor-mediated potentiation of the NMDAR-CaMKII pathway” Antioxid Redox Signal 15, 873-887 (2011). PMID: 21348811

  • RODRÍGUEZ-MUÑOZ, M., de la TORRE-MADRID, E., SÁNCHEZ-BLÁZQUEZ, P., GARZÓN, J.: “NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the Mu-opioid receptor” Antioxid Redox Signal 14, 2413-2425 (2011). PMID: 21235400

  • SÁNCHEZ-BLÁZQUEZ, P., RODRÍGUEZ-MUÑOZ, M., GARZÓN, J.: “Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling” PlosOne 5(6), e11278 (2010). PMID: 20585660

  • GARZÓN J, DE LA TORRE-MADRID E, RODRÍGUEZ-MUÑOZ M, VICENTE-SANCHEZ A, SÁNCHEZ-BLÁZQUEZ P.: Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol. Pain 5:11-21 (2009).

  • SÁNCHEZ-BLÁZQUEZ P, RODRÍGUEZ-MUÑOZ M, DE LA TORRE-MADRID E, GARZÓN J.: Brain specific Gz interact with Src tyrosine kinase to regulate MOR-NMDAR signalling pathway. Cell Signal. 21(9):1444-54 (2009).

  • BERROCOSO E, SANCHEZ-BLAZQUEZ P, GARZON J, MICO JA.: Opiates as antidepressants. Curr. Pharmac.Desing 15(14):1612-22(2009).

  • SÁNCHEZ-BLÁZQUEZ P, RODRÍGUEZ-MUÑOZ M, DE LA TORRE-MADRID E, VICENTE-SANCHEZ A, MARTIN-AZNAR B, GARZÓN J.: A study of the signalling proteins regulated by G protein-coupled receptors. Eur. J. Psychiatry 23S: 56-62 (2009).

  • SÁNCHEZ-BLÁZQUEZ P, RODRÍGUEZ-MUÑOZ M, MONTERO C, DE LA TORRE-MADRID E, GARZÓN J: Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein. Neuropharmacology 54:319-330; (2008).

  • GARZÓN J, RODRÍGUEZ-MUÑOZ M, SÁNCHEZ-BLÁZQUEZ P: Do pharmacological approaches that prevent opioid tolerance target different elements of the same regulatory machinery? Current Drug Abuse Reviews volume 1 (2); 2008.

  • GARZÓN J, SÁNCHEZ-BLÁZQUEZ P.: Mecanismos de tolerancia a los opiodes en el control del dolor. Medicina paliativa 15:365-373 (2008).

  • MOSTANY, R., DÍAZ, A., VALDIZÁN, E.M., RODRÍGUEZ-MUÑOZ, M., GARZÓN, J., HURLÉ, MA.: “Supersensitivity to μ-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Gα protein subunits” Neuropharmacology 54: 989-997 (2008).

  • RODRÍGUEZ-MUÑOZ M, DE LA TORRE-MADRID E, SÁNCHEZ-BLÁZQUEZ P, WANG J-B, GARZÓN J.: NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Cell Signal. 20:1855-1864 (2008).

  • RODRÍGUEZ-MUÑOZ M, BERMUDEZ D, SÁNCHEZ-BLÁZQUEZ P, GARZON J: Sumoylated RGS-Rz Proteins Act as Scaffolds for Mu-Opioid Receptors and G-Protein Complexes in Mouse Brain. Neuropsychopharmacology 32:842-850; (2007).

  • RODRÍGUEZ-MUÑOZ M, DE LA TORRE-MADRID E, SÁNCHEZ-BLÁZQUEZ P, GARZÓN J: Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins. Mol Pain. 3:19-32; (2007).

  • RODRÍGUEZ-MUÑOZ M, DE LA TORRE-MADRID E, GAITÁN G, SÁNCHEZ-BLÁZQUEZ P, GARZÓN J: RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons. Cell Signal. 19:2558-2571; (2007).

  • LOPEZ-FANDO, A., RODRÍGUEZ-MUÑOZ, M., SÁNCHEZ-BLÁZQUEZ, P. y GARZÓN, J.: “Expression of neural RGS-R7 and Gβ5 proteins in response to acute and chronic morphine”. Neuropsychopharmacology 30:99-110 (2005) .

  • SÁNCHEZ-BLÁZQUEZ, P., RODRÍGUEZ-MUÑOZ, M., MONTERO, C. y GARZÓN, J.: “RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitization in CNS: the role of activated Gαz subunits”. Neuropharmacology 48:138-150 (2005).

  • GARZÓN, J., RODRÍGUEZ-MUÑOZ, M., LÓPEZ-FANDO, A. y SÁNCHEZ-BLÁZQUEZ, P.: “Activation of Mu-opioid receptors transfers control of Galfa subunits to the regulator of G protein signalling RGS9-2. Role in receptor desensitization”. J. Biol. Chem. 280:8951-8960 (2005).

  • GARZÓN, J., RODRÍGUEZ-MUÑOZ, M.. y SÁNCHEZ-BLÁZQUEZ, P.: “Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periacueductal grey matter”. Neuropharmacology , 48:853-868 (2005).

  • GARZÓN, J., RODRÍGUEZ-MUÑOZ, M., de la TORRE-MADRID, E. y SÁNCHEZ-BLÁZQUEZ, P.: “Effector antagonism by RGS proteins causes densensitization of mu-opioid receptors in the CNS”. Psychopharmacology 180:1-11 (2005).

  • GARZÓN, J., RODRÍGUEZ-MUÑOZ, M., LÓPEZ-FANDO, A. y SÁNCHEZ-BLÁZQUEZ, P.: “The RGSZ2 protein exits in a complex with mu opioid receptors and regulates the sensitizing capacity of Gz proteins” Neuropsychopharmacology 30:1632-1648 (2005).

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